Complications after medullary thyroid carcinoma surgery: multicentre study of the <i>SQRTPA</i> and <i>EUROCRINE</i>® databases

Abstract Background Surgery is the curative therapy for patients with medullary thyroid carcinoma (MTC). In determining extent of surgery, risk complications should be considered. The aim this study was to assess procedure-specific outcomes and factors after surgery MTC. Methods Patients who underwent MTC were identified in two European prospective quality databases. Hypoparathyroidism defined by treatment calcium/active vitamin D. Recurrent laryngeal nerve (RLN) palsy diagnosed on laryngoscopy. Complications considered at least transient if present last follow-up. Risk at-least hypoparathyroidism RLN logistic regression analysis. Results A total 650 69 centres a median age 56 years. Hypoparathyroidism, bleeding requiring reoperation occurred 170 (26·2 per cent), 62 (13·7 cent) 17 (2·6 respectively. Factors associated central lymph node dissection (CLND) (odds ratio (OR) 2·20, 95 cent c.i. 1·04 4·67), CLND plus unilateral lateral (LLND) (OR 2·78, 1·20 6·43), bilateral LLND 2·83, 1·13 7·05) four or more parathyroid glands observed 4·18, 1·46 12·00). 4·04, 1·12 14·58) T4 tumours 12·16, 4·46 33·18). After compartment-oriented dissection, N0 status achieved 248 537 (46·2 cent). Conclusion are may relate unavoidable consequences radical needed some patients.